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18,110 Correlation with neuroimaging data for clinical grading of oligodendrogliomas is strongly warranted. Magnetic resonance imaging of oligodendrogliomas (WHO II) commonly shows minimal peritumoral edema, sharply demarcated margins (60% to 70%), hypodensity on T1-weighted sequences, and hyperdensity on T2-weighted sequences. However, variable cystic degeneration and hemorrhage can result in more heterogeneous signal intensities of mixed hypodensities and isodensities on T1-weighted images. Anaplastic Oligodendroglioma (WHO III) Anaplastic oligodendrogliomas share the histopathologic features of oligodendrogliomas WHO II in addition to the features of necrosis, microvascular hyperplasia, and high cellularity with a high mitotic activity and increased nuclear pleomorphism.

PRIMARY BRAIN TUMORS OF NONGLIAL ORIGIN Primary Cerebral Lymphoma Over the past 2 decades, the incidence of primary cerebral lymphoma (PCL) has substantially increased in both immunocompromised and immune-competent individuals—a phenomenon that cannot be entirely explained by changes in tumor classification, the increased prevalence of AIDS, or the growing number of organ transplantations. 5,18 Unlike other high-grade intracranial neoplasms, PCLs are treated with combined highdose chemotherapy and radiation therapy without surgery.

A definitive quantitative “grading” of these features as prognostic factors has been problematic. Although necrosis, increased mitotic rate, marked microvascular hyperplasia, and nuclear atypia may, in combination, be significant, extensive geographic necrosis may be a key prognostic feature. However, the molecular genetic analysis for 1p or 19q loss and other genetic aberrations, as described earlier, is an important prognostic complement to the tumor histopathology. Anaplastic tumors with brisk growth are marked by significant neovascularity and increased vascular enhancement with magnetic resonance imaging, although approximately two thirds of oligodendrogliomas (WHO II) may have a limited, patchy vascular enhancement.

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A color atlas of Complete Denture Fabrication


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